Article: Radiation response modification: novel approaches Journal: International Journal of Low Radiation (IJLR) 2010 Vol.7 No.1 pp.32 - 47 Abstract: Current limitations in the application of radiomodifiers refer to significant acute toxicity, intravenous administration for most of them and loss of most antiradiation properties when radiation types other than low Linear Energy Transfer (LET) radiation are concerned. This paper describes research on |molecular combinations| – structural modification of clinically approved preparations with biologically active compounds; incorporation in biodegradable polymers to prolong effects; and investigations with herbal preparations. Inspiring results were achieved for adenine nucleotides linked to aminothiols. Some products manifested marked therapeutic properties on the survival rate and reduction of postradiation adinamy incidence in rats after oral administration. The effect of the bond character in molecular combinations was evaluated, as well as the influence of the polymer-carrier molecular weight and degree of immobilisation. Radiosensitising preparations based on nucleotides and 2′-deoxynucleotides co-precipitation with ethanidazole were more effective in tumour-bearing mice after whole-body fractionated irradiation. In case of low-dose prolonged irradiation, the herbal preparation Elixir-3 (E-3) diminished the radiation damage and facilitated repair processes. Inderscience Publishers - linking academia, business and industry through research

Title: Radiation response modification: novel approaches

Authors: Radostina T. Georgieva

Addresses: Department of Radiobiology, National Center of Radiobiology and Radiation Protection, Ministry of Health, 132 Kliment Ohridski Blvd., Sofia, 1756, Bulgaria

Abstract: Current limitations in the application of radiomodifiers refer to significant acute toxicity, intravenous administration for most of them and loss of most antiradiation properties when radiation types other than low Linear Energy Transfer (LET) radiation are concerned. This paper describes research on |molecular combinations| – structural modification of clinically approved preparations with biologically active compounds; incorporation in biodegradable polymers to prolong effects; and investigations with herbal preparations. Inspiring results were achieved for adenine nucleotides linked to aminothiols. Some products manifested marked therapeutic properties on the survival rate and reduction of postradiation adinamy incidence in rats after oral administration. The effect of the bond character in molecular combinations was evaluated, as well as the influence of the polymer-carrier molecular weight and degree of immobilisation. Radiosensitising preparations based on nucleotides and 2′-deoxynucleotides co-precipitation with ethanidazole were more effective in tumour-bearing mice after whole-body fractionated irradiation. In case of low-dose prolonged irradiation, the herbal preparation Elixir-3 (E-3) diminished the radiation damage and facilitated repair processes.

Keywords: radiomodifiers; molecular combinations; polymer complexes; herbal preparations; low-dose radiation; low radiation; radiation response modification; structural modification; biologically active compounds; biodegradable polymers; adenine nucleotides; aminothiols; survival rate; postradiation adinamy incidence; rats; radiation damage; repair processes.

DOI: 10.1504/IJLR.2010.032769

International Journal of Low Radiation, 2010 Vol.7 No.1, pp.32 - 47

Published online: 20 Apr 2010 *

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Title: Radiation response modification: novel approaches

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