Title: Cellunomics: the interaction analysis of cells

Authors: Virendra S. Gomase, Aravind K. Tripathi, Somnath Tagore

Addresses: Department of Bioinformatics, Padmashree Dr. D.Y. Patil University, Plot No. 50, Sector 15, CBD Belapur, Navi Mumbai 400614, India. ' Department of Bioinformatics, Padmashree Dr. D.Y. Patil University, Plot No. 50, Sector 15, CBD Belapur, Navi Mumbai 400614, India. ' Department of Bioinformatics, Padmashree Dr. D.Y. Patil University, Plot No. 50, Sector 15, CBD Belapur, Navi Mumbai 400614, India

Abstract: Cellunomics envisions the new branch of cell, which integrates genomics and proteomics with a new knowledge base built from temporal and spatial data on the chemical and molecular interrelationships of cellular components, i.e., cellome. Cellunomics helps in finding cell-specific protein and protein-protein interaction using cell-specific mRNA and protein repository. A flexible statistical-model-based clustering approach is introduced for identifying cell populations and the data revealed by the cellome is informational as well as physical. Cellunomics aids the automated, high-content platforms, to increase the scope and scale of experiments traditionally executed through interactive microscopy.

Keywords: cellome; chromatography; clustering; electrophoresis; signalling; spectrometry; cell interactions; cellunomics; genomics; proteomics; cellular components; cell-specific protein; protein-protein interaction; bioinformatics.

DOI: 10.1504/IJBRA.2009.029046

International Journal of Bioinformatics Research and Applications, 2009 Vol.5 No.6, pp.674 - 690

Received: 18 Jan 2009
Accepted: 21 May 2009
Published online: 29 Oct 2009 *

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