Title: Short communication: Cadmium bioconcentration and genotoxicity in the common carp (Cyprinus carpio)

Authors: Natalia A. Ossana, Bettina L. Eissa, Alfredo Salibian

Addresses: National Council of Scientific and Technological Research (CONICET), Rivadavia 1917, C1033AAJ-Buenos Aires, Argentina. ' Department of Basic Sciences (PRODEA-INEDES), National University of Lujan, P.O. Box 221, B6700ZBA-Lujan, Argentina. ' Buenos Aires Province Scientific Research Commission (CIC), Calle 526, entre 10 y 11, 1900-La Plata, Argentina

Abstract: Heavy metals in the aquatic environment pose high ecotoxicological risk to fish. Cadmium is one of the most abundant pollutants in freshwater bodies in Argentina. An evaluation was performed of the responses of several exposure biomarkers of juvenile Cyprinus carpio exposed during five days to sublethal cadmium (0.5 mgL−1) and cyclophosphamide (5 mgL−1). The assessment involved evaluating the impact of exposures on the following parameters of fish: Condition Factor (CF), Hepatosomatic Index (HSI), tissue accumulation (brain, muscle, gills, liver and blood) and erythrocyte micronuclei (MN) frequency. Compared with controls CF showed no significant changes and HSI registered a declining tendency. The metal accumulated mainly in the gills and to a lesser proportion in the liver and blood; in the brain and muscles, the quantities determined were no different from those found in the controls. MN frequency in erythrocytes increased significantly among fish exposed both to cadmium and to cyclophosphamide.

Keywords: cadmium bioconcentration; cyclophosphamide; condition factor; hepatosomatic index; erythrocyte micronuclei test; environmental health; Cyprinus carpio; common carp; genotoxicity; heavy metals; water pollution; ecotoxicological risks; fish.

DOI: 10.1504/IJENVH.2009.028596

International Journal of Environment and Health, 2009 Vol.3 No.3, pp.302 - 309

Published online: 19 Sep 2009 *

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