Title: Patient-specific modelling of blood flow dynamics in intra-cranial aneurysms: an example of image-based personalised medicine

Authors: Christof Karmonik, Y. Jonathan Zhang, Thomas Redel, Ralf Kroeger, Robert G. Grossman

Addresses: The Methodist Hospital Neurological Institute, Houston TX, USA. ' The Methodist Hospital Neurological Institute, Houston TX, USA. ' Siemens AG, Healthcare Sector, Forchheim, Germany. ' ANSYS Germany GmbH Birkenweg 14a, 64295 Darmstadt, Germany. ' The Methodist Hospital Neurological Institute, Houston TX, USA

Abstract: The visualisation of blood flow dynamics in intracranial aneurysm using computational fluid dynamics is an example of personalised medicine based on biomedical image analysis. A small percentage of these aneurysms rupture. Blood flow dynamics is thought to play an important role in the rupture process by exerting Wall Shear Stresses (WSS) on the endothelial cells. In this study, the effects of instabilities in the velocity waveform in the parent artery of an aneurysm of the Internal Carotid Artery (ICA) and variations of the computational mesh are investigated with respect to WSS at the aneurysm wall.

Keywords: intracranial aneurysms; computational fluid dynamics; CFD; wall shear stresses; hemodynamics; cerebral blood flow; visualisation; blood flow dynamics; biomedical image analysis; rupture process; endothelial cells; instabilities; velocity waveform; internal carotid artery.

DOI: 10.1504/IJFIPM.2009.027589

International Journal of Functional Informatics and Personalised Medicine, 2009 Vol.2 No.2, pp.150 - 158

Published online: 02 Aug 2009 *

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