Title: Exploration of homodimer receptor: homodimer protein interactions

Authors: Julio Vera, Taesoo Kwon, Ulf Schmitz, Walter Kolch, Olaf Wolkenhauer

Addresses: Group of Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, 18051 Rostock, Germany. ' Division of Bio-Medical Informatics, Center for Genome Science, National Institute of Health, Korea Centers for Disease Control and Prevention, 194, TongIl-Lo, Eunpyung-Gu, Seoul 122-701, Korea. ' Group of Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, 18051 Rostock, Germany. ' The Beatson Institute for Cancer Research, Glasgow, G11 1BD, UK; University of Glasgow, Sir Henry Wellcome Functional Genomics Facility, Glasgow, G12 8QQ, UK. ' Group of Systems Biology and Bioinformatics, Department of Computer Science, University of Rostock, 18051 Rostock, Germany

Abstract: Homodimerisation is producing a protein–protein complex composed of two identical molecules. Dimerisation is a phenomenon often occurring in the regulation of biochemical systems like signal transduction pathways. We investigated whether the existence of a homodimer-activated receptor and the activation of homodimer transducers correspond to a more general pattern in cell signalling. We developed a workflow to merge data from the Gene Ontology and the BIND database to produce a list of interactions between homodimer receptors and homodimer proteins. Finally, we found a prevalence of homodimer–homodimer interactions in signalling systems in human cells.

Keywords: cell signalling; homodimerisation; homodimer receptors; homodimer proteins; transducers; protein–protein interactions; systems biology; bioinformatics; gene ontology; human cells.

DOI: 10.1504/IJBRA.2009.027518

International Journal of Bioinformatics Research and Applications, 2009 Vol.5 No.4, pp.447 - 457

Available online: 28 Jul 2009

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