Title: Abnormalities of the Corpus Callosum in autism subtype

Authors: Qing He, Ye Duan, Judith Miles, Nicole Takahashi

Addresses: Department of Computer Science, University of Missouri-Columbia, Columbia, MO, 65211, USA. ' Department of Computer Science, University of Missouri-Columbia, Columbia, MO, 65211, USA. ' Thompson Center for Autism, University of Missouri-Columbia, Columbia, MO, 65211, USA. ' Thompson Center for Autism, University of Missouri-Columbia, Columbia, MO, 65211, USA

Abstract: Brain imaging studies of the Corpus Callosum (CC) in autism have yielded inconsistent results. This paper explores the CC abnormalities in autism. The CC is segmented from 2D MRIs using our newly developed semiautomatic method, and a subsequent contour stitching is performed to create the 3D surface of the CC. After alignment, differences between autistic patients and the control group are computed using Hotelling T2 two-sample metric, which results in a raw significance map. Permutation test is performed to generate a corrected significance map. The statistical results reveal significant difference between patients and controls in the body of the CC.

Keywords: corpus callosum; utism; CC abnormalities; shape analysis; permutation test; brain imaging; contour stitching; MRI.

DOI: 10.1504/IJFIPM.2008.018295

International Journal of Functional Informatics and Personalised Medicine, 2008 Vol.1 No.1, pp.103 - 110

Available online: 14 May 2008

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