Title: Bioinformatics screening of key hub genes associated with venous thromboembolism following blunt trauma

Authors: Qianqian Sun; Wei Qi; Fei Tan; Hongwei Zhang

Addresses: Intensive Care Unit, The Second Hospital of Tangshan, Tangshan City, Hebei – 063000, China ' Trauma Orthopedics, The Second Hospital of Tangshan, Tangshan City, Hebei – 063000, China ' Intensive Care Unit, The Second Hospital of Tangshan, Tangshan City, Hebei – 063000, China ' Intensive Care Unit, The Second Hospital of Tangshan, Tangshan City, Hebei – 063000, China

Abstract: This study aimed to identify key biomarkers for venous thromboembolism (VTE) following blunt trauma. Using bioinformatics analysis of public gene expression datasets (GSE19151 and GSE36809), we screened for differentially expressed genes (DEGs) and constructed co-expression networks. Functional enrichment analysis revealed critical biological pathways, and a protein-protein interaction network was established to pinpoint central hub genes. Six hub genes (MRPL15, MRPL3, MYC, RPLP0, TP53, and CD3D) were identified, with MRPL3 and MYC showing promising diagnostic potential (AUC of 0.71 and 0.76, respectively). These findings suggest that these genes may serve as novel biomarkers for the early diagnosis of trauma-associated VTE, offering a foundation for future clinical validation and targeted therapeutic strategies.

Keywords: venous thromboembolism; VTE; biomarkers; diagnosis.

DOI: 10.1504/IJDMB.2026.154710

International Journal of Data Mining and Bioinformatics, 2026 Vol.30 No.3/4, pp.405 - 427

Received: 27 Dec 2024
Accepted: 30 Aug 2025
Published online: 10 Jul 2026 *

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