Title: Antibiotic genomic resistance prediction using deep learning models

Authors: S.M. Shifana Rayesha; W. Aisha Banu; Afzalur Rahman

Addresses: School of Computer, Information and Mathematical Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India ' School of Computer, Information and Mathematical Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India ' School of Commerce, Presidency University, Bengaluru, Karnataka, India

Abstract: The classification of antibiotic resistance genomes presents a substantial challenge in the field of computational biomedical data analysis. Several machine-learning techniques have been used to solve this challenge in recent years. However, training data that is not independent and identically distributed makes taught models prone to out-of-distribution generalisation difficulties, making it a major challenge. Antibiotic resistance data generally match observations from similar phylogenetic datasets, making this important. To identify antibiotic resistance in drug discovery, antimicrobial characteristics must be extracted from large datasets. This abstract discusses retrieving antibiotic-resistance genes from the 89,491-feature pseudomonas aeruginosa integrin nucleotide sequence. For data separation and processing, 1D CNNs and ANNs were used to handle this complex text. The model extracts antimicrobial resistance genomes efficiently in convolution neural networks. The 1D convolutional neural network has 98.85% efficiency, while the artificial neural network has 80.46 %. This article uses the convolutional neural network, which extracts antibiotic resistance genomic information well. These findings could help us understand antibiotic resistance and improve medication discovery. These cutting-edge machine-learning approaches provide hope in the fight against emerging microbial dangers in an era of antibiotic resistance.

Keywords: machine-learning; 1D convolutional neural networks; CNN; artificial neural networks; ANN; phylogenetic; nucleotide.

DOI: 10.1504/IJBRA.2025.145118

International Journal of Bioinformatics Research and Applications, 2025 Vol.21 No.2, pp.121 - 136

Received: 20 Mar 2024
Accepted: 17 Apr 2024
Published online: 19 Mar 2025 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article