Title: HDAC inhibitors and their potential towards cancer treatment

Authors: Sanjay Kumar Choubey; Sachin Kumar; Medha Kumari

Addresses: Alagappa University, Karaikudi-630004, Tamil Nadu, India ' IIMT Engineering College, O Pocket, Ganga Nagar, 250001, Meerut, U.P, India ' Vinoba Bhave University, Sindoor, Hazaribagh, 825301, Jharkhand, India

Abstract: Histone deacetylases (HDACs) play a key role in chromatin structure modulation through deacetylation of histones leading to formation of highly compact DNA-histone complex. HDACs have been reported to be implicated in multiple types of cancers. Blocking the activities of histone deacetylases will help to overcome gene repression pressure and it would be possible to check the incessant growth of cells in tumour. Therefore the interest has been developed to design the HDAC inhibitors and their analogues and histone deacetylases are now considered as potential targets for their wide distribution in various forms of cancer. HDAC inhibitors display their role by regulating cyclin dependent kinases (cdK), inducing p21 and various preapoptotic genes like Bax, Bak, repressing the activities of growth factors like VEGF, repressing transcription factor HIF-1α facilitating arrest of cell cycle, modulating various signaling pathways like STAT signaling, AMPK signaling, inducing cell adhesion molecule E-cadherin.

Keywords: cyclin dependent kinase; histone deacetylase; carcinogenesis; HDAC inhibitor.

DOI: 10.1504/IJBRA.2025.144024

International Journal of Bioinformatics Research and Applications, 2025 Vol.21 No.1, pp.26 - 49

Received: 26 Aug 2023
Accepted: 15 Apr 2024
Published online: 21 Jan 2025 *

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