Title: Uncovering the intension of Alisma orientale decoction for treating vertigo: a perspective from network analysis

Authors: Jing Huang; Lei Yang; Yizhen Lin

Addresses: Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas (Fujian Provincial University), College of Environmental and Biological Engineering, Putian University, Zixiao East Road, Putian, Fujian, China ' Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas (Fujian Provincial University), College of Environmental and Biological Engineering, Putian University, Zixiao East Road, Putian, Fujian, China ' Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants, Key Laboratory of Ecological Environment and Information Atlas (Fujian Provincial University), College of Environmental and Biological Engineering, Putian University, Zixiao East Road, Putian, Fujian, China

Abstract: Alisma orientale decoction (AOD), a traditional Chinese medicine composed of AO and AM, has a significant effect on the treatment of vertigo, improving the curative effect and reducing the likelihood of side effects with long-term stable medication. This manuscript established an interaction network between AOD and vertigo to explain, using network pharmacology, how AOD works to treat vertigo. Data mining of several databases yielded 12 candidate compounds, including eight components of AO and four components of AM, along with 331 potential targets. PPI analysis showed that the compounds acted mainly on key targets of MAPK1, EGFR, MAPK14, ERBB2, PIK3CA, MAPK8 and MTOR. In addition, GO and KEGG studies indicated that proteoglycans, ErbB signalling, HIF-1 signalling, chord metabolism, estrogen signalling, prolactin signalling and osteogenic class differentiation pathways were strongly involved in the signalling pathways of vertigo therapy. Data mining of the therapeutic targets and pathways provided new insights and considerations for drug development and clinical therapy of vertigo.

Keywords: network pharmacology; Alisma orientale decoction; AOD; vertigo; Atractylodes macrocephala.

DOI: 10.1504/IJDMB.2024.136230

International Journal of Data Mining and Bioinformatics, 2024 Vol.28 No.1, pp.58 - 72

Received: 05 Jul 2022
Accepted: 02 Oct 2023
Published online: 22 Jan 2024 *