Title: Diagnostic and prognostic value of HSPD1 in oesophageal cancer

Authors: Xin Chen; Can Luo; Yuting Bai; Xi Zhou; Lei Xu; Xiaolan Guo; Qing Wu; Xiaowu Zhong

Addresses: Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China; Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China ' Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China ' Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China ' Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China ' Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China ' Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China; Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China ' Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China ' Translational Medicine Research Centre, North Sichuan Medical College, Nanchong, Sichuan, China; Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

Abstract: HSPD1 is a potential biomarker in many cancers. However, its role in oesophageal cancer (ESCA) is poorly understood. Among patients with ESCA, a high HSPD1 expression is linked to a poor outcome. As suggested by Cox analysis results combined with ROC (receiver operating characteristic) graph, HSPD1 is an independent outcome predictor for the ESCA population and had a diagnostic value. Moreover, HSPD1 is linked to immunofiltration, genetic alteration and methylation in ESCA, which is also involved in biological processes, such as chaperonin-containing T-complex, PI3K/Akt signalling pathway, and thyroid hormone signalling pathway. According to a final analysis of drug susceptibility, low HSPD1 expression is correlated with resistance to 23 drugs. This phenomenon provided new insights for the probable predictor role of HSPD1 in the ESCA diagnosis and prognosis.

Keywords: HSPD1; oesophageal cancer; bioinformatics; prognosis; diagnosis; biomarkers.

DOI: 10.1504/IJDMB.2021.124108

International Journal of Data Mining and Bioinformatics, 2021 Vol.26 No.1/2, pp.1 - 19

Received: 10 Nov 2021
Accepted: 23 Apr 2022
Published online: 13 Jul 2022 *

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