Title: Research on drug-induced liver injury in association with co-infections and anti-tuberculosis drugs

Authors: Li-Ya Wu; Sung-Shun Weng; Wing-Wai Wong

Addresses: Division of Risk Management, Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan; Department of Information and Finance Management, National Taipei University of Technology, Taiwan; Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan ' Division of Risk Management, Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan; Department of Information and Finance Management, National Taipei University of Technology, Taiwan; Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan ' Division of Risk Management, Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan; Department of Information and Finance Management, National Taipei University of Technology, Taiwan; Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan

Abstract: This study uses data mining techniques to find out the risk factors for the tuberculosis (TB) patients with drug-induced liver injury (DILI). The Taiwan National Health Insurance Database is used for collection of domestic TB cases during 2004-2011 to study these TB patients and their drug prescribing patterns in order to build a model to predict the risk of drug-drug interaction between hepatitis B and C, acquired immune deficiency syndrome (AIDS) and TB. The results out of the total 188,032 TB patients have shown that 77,574 have taken anti-TB drugs. Afterwards, DILI occurred in 0.7% of the cases. Besides, for those DILI patients associated with TB and hepatitis B or C, this study reveals that DILI is associated with the use of ethambutol and rifampin. It is suggested that TB patients associated with hepatitis C should pay attention to their uses of rifampicin, and TB patients (especially males) associated with hepatitis B should pay attention to the ethambutol's impact on DILI. Moreover, our results also showed that having both AIDS and TB shows no significant effect on DILI.

Keywords: drug interactions; tuberculosis; data mining; drug-induced liver injury; DILI; technology.

DOI: 10.1504/IJBSR.2020.106271

International Journal of Business and Systems Research, 2020 Vol.14 No.2, pp.125 - 138

Received: 29 Nov 2017
Accepted: 16 Sep 2018
Published online: 02 Apr 2020 *

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