Article: Core genes and pathways underlying ferroptosis in chondrosarcoma pathogenesis: through bioinformatics analysis Journal: International Journal of Data Mining and Bioinformatics (IJDMB) 2026 Vol.30 No.8 pp.1 - 23 Abstract: Chondrosarcoma (CS) often resists standard radiotherapy and chemotherapy. Our study explores ferroptosis as a novel tactic to counter this resistance, investigating molecular mechanisms in CS and identifying core genes impacting patient survival rates. The database was screened for 2,821 DEGs and 471 ferroptosis-related genes. Further analysis by Gene-miRNA and PPI networks identified nine core genes (IL6, TP53, MAPK1, CAV1, GJA1, SMAD7, TXNIP, MAP3K5, and DUSP1) related to ferroptosis in CS. Lower expression of IL6, TP53, MAPK1, and SMAD7, alongside higher expression of CAV1, GJA1, TXNIP, MAP3K5, and DUSP1 were noted in CS tissues. Survival analysis demonstrated higher survival rates in CS patients with low GJA1 and high IL6 expression. In conclusion, GJA1 and IL6 may play pivotal roles in the regulation of ferroptosis in CS, and are tightly associated with the prognosis of CS patients. Inderscience Publishers - linking academia, business and industry through research

Title: Core genes and pathways underlying ferroptosis in chondrosarcoma pathogenesis: through bioinformatics analysis

Authors: Zhiqiang Ye; Zhaoyuan Wang; Zhuo Zhao; Yongxu Zhang; Bowen Zheng; Lianbo Yang; Jinghang Lu; Haidong Liang

Addresses: Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China ' Department of Aesthetic Plastic Surgery and Laser Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China ' Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China ' Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China ' Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China ' Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China ' Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China ' Department of Bone and Soft Tissue Repair and Reconstructive Surgery, The Second Hospital of Dalian Medical University, Dalian Liaoning 116000, China

Abstract: Chondrosarcoma (CS) often resists standard radiotherapy and chemotherapy. Our study explores ferroptosis as a novel tactic to counter this resistance, investigating molecular mechanisms in CS and identifying core genes impacting patient survival rates. The database was screened for 2,821 DEGs and 471 ferroptosis-related genes. Further analysis by Gene-miRNA and PPI networks identified nine core genes (IL6, TP53, MAPK1, CAV1, GJA1, SMAD7, TXNIP, MAP3K5, and DUSP1) related to ferroptosis in CS. Lower expression of IL6, TP53, MAPK1, and SMAD7, alongside higher expression of CAV1, GJA1, TXNIP, MAP3K5, and DUSP1 were noted in CS tissues. Survival analysis demonstrated higher survival rates in CS patients with low GJA1 and high IL6 expression. In conclusion, GJA1 and IL6 may play pivotal roles in the regulation of ferroptosis in CS, and are tightly associated with the prognosis of CS patients.

Keywords: ferroptosis; chondrosarcoma; GJA1; IL6.

DOI: 10.1504/IJDMB.2026.155991

International Journal of Data Mining and Bioinformatics, 2026 Vol.30 No.8, pp.1 - 23

Received: 22 Aug 2025
Accepted: 11 Mar 2026
Published online: 28 Aug 2026 *

Title: Core genes and pathways underlying ferroptosis in chondrosarcoma pathogenesis: through bioinformatics analysis

Keep up-to-date