Int. J. of Bioinformatics Research and Applications   »   2011 Vol.7, No.1

 

 

Title: Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses

 

Author: Vladislav Victorovich Khrustalev, Eugene Victorovich Barkovsky

 

Addresses:
Department of General Chemistry, Belarussian State Medical University, 83 Dzerzinskogo Prospect, Minsk 220000, Belarus.
Department of General Chemistry, Belarussian State Medical University, 83 Dzerzinskogo Prospect, Minsk 220000, Belarus

 

Abstract: The usage of cytosine in third codon positions of 22 complete Rubella virus genomes (52.4%) is significantly higher than the usage of guanine (28.9%), adenine (6.9%) and uracil (11.8%). The percentage of U ↔ C transitions (55%) between 22 Rubella virus genomes is two times higher than the percentage of A ↔ G transitions (23%). Predicted microRNA from ORF1 of Rubella virus may target human APOBEC1 mRNA, blocking APOBEC1-editing of viral RNA-minus and RNA-plus strands (preventing G → A and C → U transitions, respectively), while their ADAR-editing (causing U → C and A → G transitions, respectively) occurs frequently.

 

Keywords: rubella virus genomes; alphavirus; togaviridae; ADAR; APOBEC1; mutational pressure; microRNA; GC-content; inosine; 8-oxo-G; bioinformatics; RNA editing; nucleotide content; nucleotide content.

 

DOI: 10.1504/IJBRA.2011.039171

 

Int. J. of Bioinformatics Research and Applications, 2011 Vol.7, No.1, pp.82 - 100

 

Available online: 24 Mar 2011

 

 

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