Computational approach to reveal the modulation of Wnt and TGF-β signalling induced by Solenopsin B, an ant venom alkaloid
by Priya Das; P. Umesh; Pawan K. Dhar; Achuthsankar S. Nair; Oommen V. Oommen
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 13, No. 4, 2017

Abstract: Recently, therapeutic prospect of solenopsin A was reported with emphasis on the inhibition of angiogenesis by antagonising Akt and inhibiting insulin-mediated PI3K activation. In this study, we attempt to computationally predict the molecular genes and pathways altered by solenopsin B using microarray data. Functional analysis of differentially expressed genes i.e., gene ontology and pathway enrichment analysis using bioinformatics tools specifically indicated the gene-level variations leading to down-regulation in Wnt, ErbB and TGF-β signalling pathways.

Online publication date: Sat, 14-Oct-2017

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