Article Abstract

	Title:	Liposome encapsulated gold nanoshells for NanoPhototherapy induced hyperthermia
	Author:	Paul M. Kasili, Tuan Vo-Dinh
	Address:	Advanced Biomedical Science and Technology Group, Oak Ridge National Laboratory, 37831 Oak Ridge, TN, USA. ' Advanced Biomedical Science and Technology Group, Oak Ridge National Laboratory, 37831 Oak Ridge, TN, USA
	Journal:	International Journal of Nanotechnology 2005 - Vol. 2, No.4  pp. 397 - 410
	Abstract:	Gold nanoshells have been extensively studied since their invention and their role in both in vitro and in vivo photothermal therapy has been explored and demonstrated. In this work, we investigate liposomal delivery of gold nanoshells and evaluate their effects for in vitro NanoPhototherapy induced hyperthermia in human mammary carcinoma cells. In addition, we compare the application of liposome encapsulated gold nanoshells and free standing gold nanoshells in NanoPhototherapy. NanoPhotoTherapy induced hyperthermia was performed using a 785 nm near-infrared light from a diode laser and the in vitro effects were evaluated using nucleic acid molecular probes by fluorescence microscopy. Additionally, we monitored apoptosis by detecting capase-9 activity.
	Keywords:	gold nanoshells; liposomes; nanophototherapy; carcinoma; hyperthermia; in vitro; apoptosis.
	DOI:	10.1504/IJNT.2005.008076
		Purchase this Paper         Comment on the Paper