A flexible approach to reconstruct the genomic spatial structure by the genetic algorithm
by Yan Zhang; William Hoskins; Ruofan Xia; Xiya Xia; Jim W. Zheng; Jijun Tang
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 11, No. 1/2, 2018

Abstract: The 3D structures of the chromosomes play fundamental roles in essential cellular functions, e.g., gene regulation, gene expression, evolution. HiC technique provides the interaction density between loci on chromosomes. Several approaches have been developed to reconstruct the 3D model of the chromosomes from HiC data. However, all of the approaches are based on a particular mathematical model and lack of flexibility for new development. We introduce a novel approach using the genetic algorithm. Our approach is flexible to accept any mathematical models to build a 3D chromosomal structure. Also, our approach outperforms current techniques in accuracy.

Online publication date: Wed, 28-Mar-2018

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