Optimal H∞ insulin injection control for blood glucose regulation in IDDM patient using physiological model Online publication date: Fri, 24-Oct-2014
by Akshaya Kumar Patra; Pravat Kumar Rout
International Journal of Automation and Control (IJAAC), Vol. 8, No. 4, 2014
Abstract: This paper addresses the design of output feedback H∞ controller to deliver insulin via an implantable micro insulin dispenser for insulin-dependent diabetes mellitus (IDDM) patients. The theory of H-infinity optimal control has the feature of minimising the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a 'switching' controller that can be applied to insulin injection for blood glucose (BG) regulation in IDDM patient. The 'switching' controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements and the subsequent optimisation of a performance index that involves the solution of a 'jump' Riccati differential equation. With an appropriate IDDM patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates to maintain normoglycaemia.
Online publication date: Fri, 24-Oct-2014
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