B- and T-cell epitope mapping of human sapovirus capsid protein: an immunomics approach
by M. Ruhul Amin, Mohammad S. Siddiqui, Dilruba Ahmed, Firoz Ahmed, Anowar Hossain
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 7, No. 3, 2011

Abstract: Human sapovirus is one of the major causes of viral gastroenteritis. Although the capsid protein (VP1) confers antigenic cross-reactivity, immunity against sapovirus is still unclear. Using immunoinformatics approach, we defined putative T- and B-cell epitopes of VP1 and mapped on to its predicted three-dimensional structure. Identified five putative T-cell epitopes also occupied the putative B-cell epitope region. These putative epitopes were conserved in all existing serotypes. Predicted epitopes can be generated through proteasome cleavage and may be useful in designing peptide-based subunit vaccine to confer both humoral and cell-mediated immunity.

Online publication date: Tue, 02-Aug-2011

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