From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: a link to rational vaccine design? – A review
by Mirjana Pavlovic, Michelle Cavallo, Anna Kats, Alex Kotlarchyk, Hanqi Zhuang, Yehuda Shoenfeld
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 7, No. 3, 2011

Abstract: Specific entities of naturally-occurring DNA hydrolytic/cytotoxic antibodies (abzymes) are linked to autoimmune and lymphoproliferative disorders. Suggested sequence of underlying activities conform to such entities penetrating the living cells, trans-locating to nucleus and recognising specific binding sites within single- or double-stranded DNA. Their origin is unknown since corresponding immunogens are unidentified. These anti-DNA antibodies could be the organism's immune response to microbial attack. Their structure, function and pathogenicity were investigated in wet-lab and via bioinformatics in context of Rational Vaccine Designs. This paper offers a comprehensive critical review on the subject in the light of known and newly proposed concepts.

Online publication date: Tue, 02-Aug-2011

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