Near-infrared imaging of balb/c mice injected with a detoxified botulinum neurotoxin A
by Martha Hale, Stephen Riding, Bal Ram Singh
The Botulinum J. (TBJ), Vol. 1, No. 4, 2010

Abstract: Identifying pathways taken by Botulinum Neurotoxins (BoNTs) in vivo is an important step to delineate therapeutic windows of opportunity and design countermeasures against them. Because of their high toxicity, tracking the toxin's biodistribution has not been possible. The current preliminary report showed that the toxin's movement in vivo could be followed by using a non-toxic version of type A botulinum neurotoxin (drBoNT/A) labelled with a dye that fluoresces in the Near-Infrared (NIR) spectrum.

Online publication date: Thu, 17-Mar-2011

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