Title: Influence of erythrocyte shape on platelet scattering towards vessel wall

Authors: Thakir D. Almomani; Suleiman Bani Hani; Ahmad Bdour; Amer A. Alsaraira; Othman Smadi; Ahmad Al-Jarrah; Rula Abdallat; Samer Awad

Addresses: Department of Biomedical Engineering, The Hashemite University, Zarqa 13115, Jordan ' Department of Mechatronics Engineering, The Hashemite University, Zarqa, Jordan ' Department of Civil Engineering, The Hashemite University, Zarqa, Jordan ' Department of Biomedical Engineering, The Hashemite University, Zarqa 13115, Jordan ' Department of Biomedical Engineering, The Hashemite University, Zarqa 13115, Jordan ' Department of Mechatronics Engineering, The Hashemite University, Zarqa, Jordan ' Department of Biomedical Engineering, The Hashemite University, Zarqa 13115, Jordan ' Department of Biomedical Engineering, The Hashemite University, Zarqa 13115, Jordan

Abstract: Red Blood Cell (RBC) geometry forms unique distinguished shape. This shape is thought to have a major influence on both the function and the dynamics of the moving erythrocyte. The shape of the RBC is hypothesised to cause platelet scattering and diffusion towards vessel wall. The current study is built to provide a detailed review of the previous theories that discuss the influence of RBC shape on its functionality and dynamics, a detailed focus on the influence of RBC dynamics on platelet migration towards the vessel wall is presented. Afterwards, computational results representing the influence of RBC shape on platelet migration to the vessel wall are listed. The results involve comparison between circular and elliptical RBCs using low Reynolds number channel flow regime. It is shown that this migration process is primarily affected by the diameter of the RBC and not by its shape.

Keywords: erythrocyte shape; biconcave; deformation; platelets; platelet migration; interaction; wall region; platelet scattering; vessel wall; red blood cell geometry; red blood cells; low Reynolds number channel flow; cell diameter.

DOI: 10.1504/IJBET.2016.078289

International Journal of Biomedical Engineering and Technology, 2016 Vol.21 No.3, pp.264 - 278

Received: 13 Jun 2015
Accepted: 02 Nov 2015

Published online: 14 Aug 2016 *

Full-text access for editors Full-text access for subscribers Purchase this article Comment on this article