Title: Bilirubin phototransformation in vitro using a battery-powered, solar-charged, high-intensity blue light-emitting diode phototherapy blanket

Authors: Harel Rosen; Jerome J. Hric; Arye Rosen; Danielle Rosen; Shalom Komornik; Kathy Zaleski; Susan Yaron

Addresses: Onsite Neonatal Partners, Inc., Voorhees, NJ, USA ' Onsite Neonatal Partners, Inc., Voorhees, NJ, USA ' AMT, Inc., Cherry Hill, NJ, USA ' AMT, Inc., Cherry Hill, NJ, USA ' AMT, Inc., Cherry Hill, NJ, USA ' Riddle Memorial Hospital, Media, PA, USA ' Riddle Memorial Hospital, Media, PA, USA

Abstract: The availability of new, higher intensity Blue Light-Emitting Diodes (LEDs), as used in the development of our LED phototherapy blanket, led us to hypothesise that our blue LED phototherapy system would phototransform bilirubin more rapidly, in vitro, than the current commercially available, state-of-the-art phototherapy system. Furthermore, we theorised that increasing light intensity, beyond levels previously studied, would lead to increasing rates of bilirubin phototransformation.

Keywords: bilirubin phototransformation; biomedical engineering; blue LEDs; light emitting diodes; LED phototherapy blanket; haemoglobin; unconjugated bilirubin; conjugated bilirubin; hyperbilirubinemia; haemolytic anaemia; bilirubin isomers; photochemical; solar charged LEDs; high intensity LEDs; in vitro phototransformation; light intensity.

DOI: 10.1504/IJBET.2014.060988

International Journal of Biomedical Engineering and Technology, 2014 Vol.15 No.1, pp.18 - 28

Received: 23 Jan 2014
Accepted: 21 Mar 2014
Published online: 21 Oct 2014 *

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