Title: Part 2: Effectiveness of a novel gentamicinpalmitate coating on biofilm formation of Staphylococcus aureus and Staphylococcus epidermidis

Authors: Klaus-Dieter Kuhn, Jorg Brunke

Addresses: Department of Adolescent and Pediatric Surgery, Medical University of Graz, Auenbruggerplatz 34 A-8036 Graz, Austria. ' Bio-Gate AG Neumeyerstrasse 48-90411 Nurnberg, Germany

Abstract: Commercially available Tilastan® layers of uncemented implants were coated with gentamicinpalmitate; no biofilm formation occurred with the novel coating. Gentamicinpalmitate is anti-infective and successfully inhibits biofilm formation of Staphylococcus aureus and/or Staphylococcus epidermidis. The gentamicin (as sulphate) of well known antibiotic impregnated bone cements and the gentamicin of the novel coating (as palmitate) that is described show comparable anti-infective behaviour within the proliferation assay according to ISO DIN EN 17025. Furthermore, the gentamicinpalmitate coating is biocompatible according to ISO DIN EN 10993.

Keywords: gentamicinpalmitate coating; gentamicin base; microporous surfaces; gentamicinsulphate; gentamicin release; uncemented titanium implants; PMMA bone cement; Tilastan; anti-infective coating; health economics; hip stems; knees; biomaterials; polymethyl methacrylate; infection risk; Staphylococcus aureus; Staphylococcus epidermidis; proliferation test.

DOI: 10.1504/IJNBM.2010.036111

International Journal of Nano and Biomaterials, 2010 Vol.3 No.1, pp.107 - 117

Published online: 19 Oct 2010 *

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