Title: The relation between leptin and osteocalcin and various anthropometric measures in preterm and full-term babies
Authors: Nermine H. Amr, Salwa Reda El-Batrawy, Shereen H. Atef, Rasha F. Darwish, Adham M. Hegazy
Addresses: Department of Pediatrics, Faculty of medicine, Ain Shams University, 10 Elzahraa Street, Dokki, Giza, Cairo, Egypt. ' National Research Center, Ain Shams University, 22 Ahmed El-Zomer Street, Apt 22, Nasr City, Cairo, Egypt. ' Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Abbassyia, Cairo, Egypt. ' Department of Pediatrics, Ain Shams University Hospitals, Abbassyia, Cairo, Egypt. ' Department of Pediatrics, Faculty of Medicine, Ain Shams University, 22 Ahmed El-Zomer Street, Apt 22, Nasr City, Cairo, Egypt
Abstract: Leptin plays a role in foetal growth. Osteocalcin, a bone specific protein, reflects bone formation rate. This study aims to investigate the effect of leptin and osteocalcin on physical growth of newborns. About 40 full-term and 41 preterm healthy babies were included. Umbilical cord samples were analysed for leptin and osteocalcin. Anthropometric measurements were taken on newborns. Leptin was significantly higher in full terms compared to preterms with no significant difference in osteocalcin. A significant positive correlation existed between leptin and anthropometric measurements in both groups. Osteocalcin was positively correlated in full terms and negatively correlated in preterms with most measurements. A positive correlation between leptin and osteocalcin was found in full terms only. The study documented the association of leptin and osteocalcin with physical growth of full-term babies. This was true regarding leptin in preterms, but not osteocalcin which could be explained by excess bone turnover in preterms.
Keywords: leptin; osteocalcin; anthropometric measures; preterm babies; full-term babies; foetal growth; bone formation; newborns.
International Journal of Food Safety, Nutrition and Public Health, 2010 Vol.3 No.1, pp.1 - 15
Published online: 04 Mar 2010 *Full-text access for editors Access for subscribers Purchase this article Comment on this article