Title: Synthesis and evaluation of regenerated cellulose and fibrin biocomposite impregnated with silver nanoparticles as a wound dressing material

Authors: Md Iqbal Niyas Ahamed; Patel Mohammed Kashif; Samickannu Sankar; Thotapalli Parvathaleswara Sastry

Addresses: Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur, 635601, India ' Department of Biochemistry, Islamiah College (Autonomous), Vaniyambadi, 635751, India ' Instrumentation Division, Central Leather Research Institute (CLRI), Adyar, Chennai 600020, India ' Bio-Products Laboratory, Central Leather Research Institute, Adyar, Chennai 600020, India

Abstract: In the present study, a composite wound dressing material containing fibrin (F) and regenerated cellulose (RC) impregnated with silver nanoparticles (Ag) with and without antibiotic gentamicin (G) were primed. The biocomposites prepared were characterised for their physicochemical investigation using conventional techniques. The results obtained showed that with the increase of fibrin level in the complex results in a reduction in its water absorption ability. The FTIR and SEM studies have shown the composite nature of the biocomposites prepared. RC-F-Ag and RC-F-Ag-G composites were used as wound dressing materials on experimental wounds of rats. The healing pattern of the wounds was evaluated by planimetric studies, macroscopic observations and biochemical studies. The results have shown faster healing patterns in the wounds treated with RC-F-Ag and RC-F-Ag-G composites compared to untreated controls. This study suggests RC-F-Ag biocomposite may be a potential candidate as a wound dressing material and may be tried on the clinical wounds of animals before being applied on humans.

Keywords: fibrin; regenerated cellulose; RC; silver nanoparticles; wound healing; biocomposite.

DOI: 10.1504/IJNBM.2019.101760

International Journal of Nano and Biomaterials, 2019 Vol.8 No.2, pp.146 - 162

Received: 04 May 2018
Accepted: 24 Oct 2018

Published online: 26 Aug 2019 *

Full-text access for editors Access for subscribers Purchase this article Comment on this article