PVP treatment of PS/PtOEPK sensor films for improved adherence of cancer cells
by Louise Orcheston-Findlay; Azadeh Hashemi; Volker Nock; Ashley Garrill
International Journal of Nanotechnology (IJNT), Vol. 15, No. 8/9/10, 2018

Abstract: Cancer cells resist some anti-cancer drugs in a hypoxic environment, which is often present in-vivo due to high proliferation rates and inadequate vasculature in dense tumour cores. Oxygen control and measurement are therefore valuable tools in culturing cancer cells in an in-vivo-like microenvironment. We report on the polyvinylpyrrolidone (PVP) treatment of polystyrene (PS)/platinum(II) octaethylporphyrin ketone (PtOEPK) fluorescent oxygen sensor films. This treatment improves cell attachment and subsequent long-term cell culture compared to native PS/PtOEPK sensor films by decreasing the water contact angle of the films to 19^o, whilst sensor sensitivity to oxygen remains high (I₀/I₁₀₀ = 12).

Online publication date: Fri, 22-Mar-2019

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