Enhancing the resolution of bioimprinted casein microdevices Online publication date: Fri, 22-Mar-2019
by Azadeh Hashemi; Volker Nock; Maan Alkaisi; Azam Ali
International Journal of Nanotechnology (IJNT), Vol. 15, No. 8/9/10, 2018
Abstract: Capturing a 3D imprint of cellular morphology into a rigid biodegradable material can significantly improve the application of such materials as substrates in tissue engineering and as structural materials in implants [1]. Previous work on culturing cells on patterned substrates with bioimprinted surface features, fabricated from non-biodegradable materials such as polystyrene (PS), has shown the influence of these patterns on cell regulation and proliferation [2]. We have recently proposed the incorporation of such biomimetic tissue-like surface features onto biodegradable materials and demonstrated a process of transferring bioimprinted surface patterns into casein-based substrates [3]. The previous replication process, even though successful, exhibited limited resolution for sub-micrometre cellular features on the final casein films. In this paper we thus present a modified replication process capable of significantly improving the replication resolution. We also demonstrate for the first time a direct comparison of cellular features of individual original cells, and their primary and secondary replications in polydimethylsiloxane (PDMS) and biodegradable casein films.
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