Protein sub-cellular localisation prediction by analysis of short-range residue correlations
by Jian Guo, Yuanlie Lin, Zhirong Sun
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 2, No. 2, 2006

Abstract: Sub-cellular localisation performs an important role in genome analysis. This paper describes a new residue-couple model using a support vector machine to predict the sub-cellular localisation of proteins. This new approach provides better predictions than the existing methods. The total prediction accuracies on Reinhardt and Hubbard's dataset reach 92.0% for prokaryotic protein sequences and 86.9% for eukaryotic protein sequences with fivefold cross validation. For a new dataset with 8304 proteins located in eight sub-cellular locations, the total accuracy achieves 88.9%. Meanwhile, the model shows robust against N-terminal errors in the sequences.

Online publication date: Tue, 09-May-2006

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