Quantitative optimisation of MRI contrast agent dose using response surface modelling
by M.A. Fkirin; Samir Mohammed Badway; Ehab Barakat
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 22, No. 1, 2016

Abstract: Nevertheless that Contrast Agent (CA) has adverse effect on patients, besides its relatively high cost, it is used in 30-40% of Magnetic Resonance Imaging (MRI) for tissue specificity. Our aim is to optimise (minimise) needed dose by studying the efficacy of magnetising CA before scanning on its signal-to-noise ratio (SNR). One set of seven samples of gadodiamide in saline were magnetised with a permanent magnet before being placed in phantoms (S1), in addition to another identical set but not magnetised (S2) (reference set) are imaged in a closed 1.5 T MRI. Both sets of Phantoms are with different CA concentration (0, 0.33, 0.66, 0.99, 1.3, 1.7, 2 mM). S1 is scanned from 0-5 hours after magnetisation, while S2 scanned once. By implementing RSM, results shows that CA could be decreased by 28% to 37.60% if externally magnetised before scanning.

Online publication date: Thu, 08-Sep-2016

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