Does a very low dose of chronic γ-irradiation induce a neuron loss in mice? Online publication date: Fri, 30-Sep-2005
by L. Collin, M. Lacroix-Triki, C. Caratero, S. Jozan, M. Courtade
International Journal of Low Radiation (IJLR), Vol. 2, No. 1/2, 2006
Abstract: Little is known about the effects of a very low dose of chronic irradiation on the brain. We have analysed brain sections from continuously irradiated (10 cGy/year - γ-rays) and control C57Bl/6J mice at various times. We have established a neuron/astrocyte ratio in the CA1 of the hippocampus, measured the glutathione content of the hippocampus area and looked for the presence of PCNA-positive cells suggestive of immature stem cells. No difference was observed in the neurone/astrocyte ratio either with ageing or after irradiation. There was a significant increase in the glutathione content in the hippocampus area with ageing and after 24 months of irradiation. A slight increase of PCNA-positive cells was observed with ageing, especially after irradiation. These results suggest that a chronic very low dose of γ-irradiation does not induce a neuron loss. Increased levels of glutathione and of PCNA-positive cells may suggest an adaptation of brain cells to the radiation factor.
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