LUM-driven micromanipulator for cell wall perforation Online publication date: Mon, 18-Apr-2016
by Ran-Ran Geng; Zhi-Yuan Yao; James K. Mills
International Journal of Mechatronics and Automation (IJMA), Vol. 5, No. 2/3, 2015
Abstract: Cell manipulation is a key technique in biotechnology today and micromanipulators are indispensable for cell manipulations. This paper presents a 3-DOF micromanipulator used for cell wall perforation which is driven by linear ultrasonic motors (LUM). The proposed micromanipulator realises a large operational workspace space as well as high precision, due to the significant advantages of LUM actuators. Finite element analysis (FEA) was used to simulate the vibration characteristics of the motors and platforms. The driving control system consists of a closed-loop system and a position feedback module, which can regulate the displacement and velocity in collaboration with the host computer. The motion stroke and displacement resolution of the micromanipulator are 80 mm × 80 mm × 30 mm and 50 nm respectively. The experiments show that the position precision is less than 0.36 µm, which is sufficiently accurate for cell manipulations. Single cell perforation experiments illustrate that this micromanipulator is useful in micro/nano biological manipulations.
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