Simultaneous alignment and structure prediction of three RNA sequences
by Beeta Masoumi, Marcel Turcotte
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 1, No. 2, 2005

Abstract: Comparative RNA sequence analyses have contributed remarkably accurate predictions. The recent determination of the 30S and 50S ribosomal subunits bringing more supporting evidence. Several inference tools are combining free energy minimisation and comparative analysis to improve the quality of secondary structure predictions. This paper investigates the following hypotheses: the use of three input sequences improves the average accuracy compared to predictions based on two input sequences; the worse prediction (minimum accuracy) for any sequence should be more accurate when three input sequences are used rather than two; finally, the consensus structure of three sequences is probably less representative of the individual sequences. The average coverage should be less.

Online publication date: Sat, 06-Aug-2005

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Bioinformatics Research and Applications (IJBRA):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com