Drug elution model of coronary stent: effects of stent embedment and binding of drug Online publication date: Sat, 16-Jan-2016
by Akash Pradip Mandal; Prashanta Kumar Mandal
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 20, No. 2, 2016
Abstract: Of concern is the transport of drug into and through the arterial wall from an embedded drug-eluting stent (DES), having struts of circular cross-section. The presence of the specific binding site action is modelled using a reversible chemical reaction. A mathematical model is developed where the free drug transport is considered as an unsteady convection-diffusion-reaction process, while the bound drug as a reaction-diffusion process. An explicit finite difference scheme has been used to tackle the governing equations of motion together with the realistic boundary conditions. Results include a parametric study, showing the spatio-temporal drug uptake and its retention in the arterial tissue, providing an understanding of how the strut embedment, diffusivity and reversible binding affect the distribution and binding of drug in the arterial tissue. The graphical results are consistent with those of previous investigations which further validate the applicability of the present model.
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