Assessing protein-protein interactions based on the semantic similarity of interacting proteins
by Guangyu Cui; Byungmin Kim; Saud Alguwaizani; Kyungsook Han
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 13, No. 1, 2015

Abstract: The Gene Ontology (GO) has been used in estimating the semantic similarity of proteins since it has the largest and reliable vocabulary of gene products and characteristics. We developed a new method which can assess Protein-Protein Interactions (PPI) using the branching factor and information content of the common ancestor of interacting proteins in the GO hierarchy. We performed a comparative evaluation of the measure with other GO-based similarity measures and evaluation results showed that our method outperformed others in most GO domains.

Online publication date: Thu, 30-Jul-2015

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