In vitro assessment on immunomodulatory effects of Lactobacillus collinoides
by A. Ashretha Latha; U. Aarthy; R.B. Narayanan
International Journal of Medical Engineering and Informatics (IJMEI), Vol. 7, No. 3, 2015

Abstract: Lymphoproliferation, cytokine gene expression and apoptosis was studied in the peripheral blood mononuclear cells (PBMCs) of ten normal individuals stimulated in vitro with live and heat killed L. collinoides. Live L. collinoides induced higher levels of lymphoproliferation compared to heat killed preparation. Both live and heat killed L. collinoides stimulated cultures exhibited enhanced IL-2 and IFN-γ gene expression to the same degree compared to the expression of IL-4 and IL-10 genes. Nitric oxide levels were elevated in the culture supernatants of live L. collinoides stimulated cultures compared to the heat killed ones. Neither of the L. collinoides preparations induced apoptosis in the PBMCs. Antibodies to L. collinoides were not detected in the sera of these individuals. These findings suggest that Lactobacillus collinoides promotes preferentially Th1 type immune response.

Online publication date: Sat, 27-Jun-2015

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