Control of solvated crystallisation of α-lactose monohydrate
by Amira Rachah; Dominikus Noll; Fabienne Espitalier; Fabien Baillon
International Journal of Mathematical Modelling and Numerical Optimisation (IJMMNO), Vol. 6, No. 2, 2015

Abstract: We present a mathematical model of solvated crystallisation of α-lactose monohydrate and discuss strategies to control the crystallisation process in semi-batch mode with the goal to privilege the production of small particles in the range between 130 µm and 330 µm. We compare specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed.

Online publication date: Tue, 16-Jun-2015

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