Effect of buthionine sulphoximine, cysteine and dithitreitol in cells exposed to low doses of radiation
by J.C. De Luca; D.M. López-Larraza
International Journal of Low Radiation (IJLR), Vol. 9, No. 5/6, 2014

Abstract: The goal of this study is to determine whether cysteimine, buthionine sulphoximide and dithitreitol protect CHO K1 cells against chromosomal aberrations induced by low doses of X-radiation, as well as whether radiation protection is related to physical properties of those thiols. Experimental design included four different treatments: (a) control, (b) cells treated with 5 mM of buthionine sulphoximide as well as cysteine and dithitreitol, (c) cells treated with 100 mGy of X-rays and (d) cells treated with 5 mM of each thiol and 100 mGy X-rays. In combined treatment, all chemical compounds were added 30 min before irradiation and remained until cell sacrifice (18 h). None of the three compounds studied showed a radioprotector effect. These results are consistent with the electrical charges and chemical structure of the three thiols.

Online publication date: Fri, 27-Mar-2015

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Low Radiation (IJLR):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com