Low-dose ionising radiation effects: effects of thoron inhalation Online publication date: Thu, 23-Oct-2014
by Aditya Menon; R. Indu; Tiju Chacko; Cherupally Krishnan Krishnan Nair
International Journal of Low Radiation (IJLR), Vol. 9, No. 4, 2014
Abstract: Cellular DNA damage, tissue antioxidant levels, serum parameters, blood count and histopathological alterations were examined in tissues of mice exposed to thoron (average radiation dose 0.065 µSv/hr). Alkaline comet assay results indicated that inhalation of thoron caused significant increase in the damage to DNA of lung tissue, while there was no significant damage to DNA in bone marrow cells. A small increase in cellular DNA damage was also seen in blood leukocytes following thoron exposure. Inhalation of thoron induced severe damage in the lung cells leading to their elimination by apoptosis. Histology of lungs showed areas of abnormalities. An increase in the level of inflammatory response mediator, NF-κB, was also observed in the lung tissue of exposed mice. The DNA damage in lung cells could be induced by high energy radiation emanating from radioactive decay of thoron and its progeny particularly the alpha radiation of 8.88 MeV from 212Po.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Low Radiation (IJLR):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook