PMS6: a fast algorithm for motif discovery
by Shibdas Bandyopadhyay; Sartaj Sahni; Sanguthevar Rajasekaran
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 10, No. 4/5, 2014

Abstract: We propose a new algorithm, PMS6, for the (l,d)-motif discovery problem in which we are to find all strings of length l that appear in every string of a given set of strings with at most d mismatches. The run time ratio PMS5/PMS6, where PMS5 is the fastest previously known algorithm for motif discovery in large instances, ranges from a high of 2.20 for the (21,8) challenge instances to a low of 1.69 for the (17,6) challenge instances. Both PMS5 and PMS6 require some amount of pre-processing. The pre-processing time for PMS6 is 34 times faster than that for PMS5 for (23,9) instances. When pre-processing time is factored in, the run time ratio PMS5/PMS6 is as high as 2.75 for (13,4) instances and as low as 1.95 for (17,6) instances.

Online publication date: Fri, 24-Oct-2014

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