Optimisation of miRNA-mRNA relationship prediction using biological features
by Jasjit K. Banwait; Hesham H. Ali; Dhundy R. Bastola
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 7, No. 1, 2014

Abstract: MicroRNAs are small (approx. 22nt) non-coding RNAs that regulate the expression of genes by either degrading messenger-RNA (mRNA) that has already been transcribed or by repressing the translation of mRNA, thus inhibiting protein production. This mechanism of gene regulation by binding of the miRNA to 3-prime-untranslated region of target mRNAs has been recently discovered. This sequence-specific post-transcriptional gene regulation process affects large set of genes involved in number of biological pathways. Mapping of 7nt long miRNA seed sequence to the target gene has been a standard way of predicting miRNA targets. In this study, we develop a framework to enrich the human miRNA-mRNA relationship based on genomic and structural information.

Online publication date: Tue, 21-Oct-2014

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