Identification of glioma cancer-alerted gene markers based on a diagnostic outcome correlation analysis preferential approach
by Bin Han; Haifeng Lai; Ruifei Xie; Lihua Li; Lei Zhu
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 9, No. 1, 2014

Abstract: Identifying glioma cancer-alerted genetic markers through analysis of microarray data allows us to detect tumours at the genome-wide level. To this end, we propose to identify glioma gene markers based primarily on their correlation with the glioma diagnostic outcomes, rather than merely on the classification quality or differential expression levels, as it is not the classification or expression level per se that is crucial, but the selection of biologically relevant biomarkers is the most important issue. With the help of singular value decomposition, microarray data are decomposed and the eigenvectors corresponding to the biological effect of diagnostic outcomes are identified. Genes that play important roles in determining this biological effect are thus detected. Therefore, genes are essentially identified in terms of their strength of association with diagnostic outcomes. Monte Carlo simulations are then used to fine tune the selected gene set in terms of classification accuracy. Experiments show that the proposed method achieves better classification accuracies and is data sets independent. Graph-based statistical analysis showed that the selected genes have close relationships with glioma diagnostic outcomes. Further biological database and literature study confirms that the identified genes are biologically relevant.

Online publication date: Tue, 21-Oct-2014

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Data Mining and Bioinformatics (IJDMB):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com