Template-based scoring functions for visualising biological insights of H-2K^b-peptide-TCR complexes
by I-Hsin Liu; Yu-Shu Lo; Jinn-Moon Yang
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 8, No. 3, 2013

Abstract: Major Histocompatibility Complex (MHC), peptide and T-Cell Receptor (TCR) play an essential role of adaptive immune responses. Many prediction servers are available for identification of peptides that bind to MHC class I molecules but often lack detailed interacting residues for analysing MHC-peptide-TCR interaction mechanisms. This study considers both the interface similarity and the interacting force for identifying binding models. Our model, considering both the MHC-peptide and the peptide-TCR interfaces, is able to provide visualisation and the biological insights of binding models. We believe that our model is useful for the development of peptide-based vaccines.

Online publication date: Mon, 20-Oct-2014

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