Pre-clinical assessment of anti-vascular drugs using quantitative dynamic contrast-enhanced MRI
by Inna V. Linnik; Steve R. Williams; Karen E. Davies; Alan T. McGown; John A. Hadfield; David L. Buckley
International Journal of Medical Engineering and Informatics (IJMEI), Vol. 4, No. 4, 2012

Abstract: The effect of novel anti-cancer agents on the vascular properties of radiation-induced fibrosarcomas in C3H-strain mice was evaluated in vivo using dynamic contrast-enhanced (DCE) MRI. A T₁-weighted volume acquisition was used to obtain DCE-MRI data. Pre-contrast T₁ measurements and the contrast agent arterial input function were used to estimate the volume transfer constant (K^trans) and extravascular extracellular volume fraction (v_e). Five novel combretastatin analogues, combretastatin A-4 (CA-4) and hazelnut oil (vehicle) were tested for their effect 24 hours after administration on the tumours. Three of the five agents and the positive control (CA-4), significantly decreased tumour K^trans and v_e: K^trans for CA-4 by 72%; fluorocombretastatin by 75%; methylcombretastatin by 68%; and ve by 40% for methylcombretastatin and 75% for the combretastatin quinone. These agents were recommended for further consideration. These results suggest that DCE-MRI may be a useful tool for pre-clinical evaluation of anti-cancer drugs.

Online publication date: Mon, 11-Aug-2014

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