Tri-mean-based statistical differential gene expression detection
by Zhaohua Ji; Chunguo Wu; Yao Wang; Renchu Guan; Huawei Tu; Xiaozhou Wu; Yanchun Liang
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 6, No. 3, 2012

Abstract: Based on the assumption that only a subset of disease group has differential gene expression, traditional detection of differentially expressed genes is under the constraint that cancer genes are up- or down-regulated in all disease samples compared with normal samples. However, in 2005, Tomlins assumed and discussed the situation that only a subset of disease samples would be activated, which are often referred to as outliers.

Online publication date: Wed, 17-Dec-2014

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