Polymer-liposome nanoparticles obtained by the electrostatic bio-adsorption of natural polymers onto soybean lecithin liposomes
by Sergio Madrigal-Carballo; Marianelly Esquivel; Germain Esquivel-Hernandez; Sergio Ramírez-Amador; María Sibaja; José Vega-Baudrit; Amparo O. Vila
International Journal of Nanoparticles (IJNP), Vol. 5, No. 3, 2012

Abstract: This work is focused on the formulation of polymer-liposome nanoparticles based on the electrostatic bio-adsorption of natural polymers onto soybean lecithin liposomes, with potential as novel delivery system for macromolecules, such as proteins. The building up of the polymer-liposome nanoparticles was achieved through the alternating bio-adsorption of natural cationic (chitosan) and neutral (dextran) or anionic (dextran sulphate or alginate) polymer layers on a core composed by anionic nanosized soybean lecithin liposomes. The electrostatic bio-adsorption of natural polymers succeeded in building nanosized, spherical, monodisperse and stable polymer-liposome nanoparticles with cumulative sizes between 357.3 nm ± 25.3 nm and 498.2 nm ± 69.6 nm and surface charges (ζ-potential) between −30.66 mV ± 1.55 mV and −26.74 mV ± 1.04 mV for the liposomal systems composed by alternating layers of chitosan and dextran sulphate or alginate, respectively. Natural-polymer-liposome nanoparticles offer good properties for encapsulation on its liposomal aqueous core and sustained release of a model protein, BSA, in vitro.

Online publication date: Wed, 20-Aug-2014

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanoparticles (IJNP):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com