Simplified light transport model for irradiation dose calculation of photodynamic therapy
by Gemunu Happawana; Amaranath Premasiri; Arye Rosen
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 9, No. 1, 2012

Abstract: A proper combination of photosensitising agent, oxygen, and a specific wavelength of light is necessary for the cytotoxic destruction of cancerous cells by Photodynamic Therapy (PDT). For a light source, semiconductor lasers are suggested for the light delivery system, however packaging of semiconductor lasers for optimal optical power output is challenging. In this paper an optimal design of a semiconductor laser package with De-Ionised (DI) water-cooling system is described and analysed. A microwave antenna is designed to provide local heating of the esophagus, leading to an increase in local oxygenation of the tumor to generate singlet oxygen for cellular death.

Online publication date: Fri, 12-Dec-2014

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