Simplified light transport model for irradiation dose calculation of photodynamic therapy Online publication date: Fri, 12-Dec-2014
by Gemunu Happawana; Amaranath Premasiri; Arye Rosen
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 9, No. 1, 2012
Abstract: A proper combination of photosensitising agent, oxygen, and a specific wavelength of light is necessary for the cytotoxic destruction of cancerous cells by Photodynamic Therapy (PDT). For a light source, semiconductor lasers are suggested for the light delivery system, however packaging of semiconductor lasers for optimal optical power output is challenging. In this paper an optimal design of a semiconductor laser package with De-Ionised (DI) water-cooling system is described and analysed. A microwave antenna is designed to provide local heating of the esophagus, leading to an increase in local oxygenation of the tumor to generate singlet oxygen for cellular death.
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