New encoded single-indicator sequences based on physico-chemical parameters for efficient exon identification
by J.K. Meher; P.K. Meher; G.N. Dash; M.K. Raval
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 8, No. 1/2, 2012

Abstract: The first step in gene identification problem based on genomic signal processing is to convert character strings into numerical sequences. These numerical sequences are then analysed spectrally or using digital filtering techniques for the period-3 peaks, which are present in exons (coding areas) and absent in introns (non-coding areas). In this paper, we have shown that single-indicator sequences can be generated by encoding schemes based on physico-chemical properties. Two new methods are proposed for generating single-indicator sequences based on hydration energy and dipole moments. The proposed methods produce high peak at exon locations and effectively suppress false exons (intron regions having greater peak than exon regions) resulting in high discriminating factor, sensitivity and specificity.

Online publication date: Fri, 05-Dec-2014

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