T-cell receptor variable beta (1-24) gene repertoire in patients with Wuchereria bancrofti infections
by M.S. Sudhakar; K.V. Alala Sundaram; R.B. Narayanan
International Journal of Medical Engineering and Informatics (IJMEI), Vol. 4, No. 1, 2012

Abstract: T-cell receptor V beta (TCRV_β) gene repertoire (Vβ1-Vβ24) was evaluated in the peripheral blood mononuclear cells (PBMCs) from asymptomatic and amicrofilaremic normal individuals (EN), and patients with chronic pathology (CP) harbouring Wuchereria bancrofti. TCRV_β gene expression in phytohemagglutinin (PHA) stimulated PBMC cultures from EN and CP individuals was in the order EN > CP while in Brugia malayi adult antigen (BmA) or purified protein derivative from mycobacterium tuberculosis (PPD) stimulation or the unstimulated conditions, the order was CP > EN. Thus, the PBMCs of the CP patients showed elevated levels of TCRV_β gene expression both in the unstimulated and stimulated conditions compared to EN.

Online publication date: Mon, 11-Aug-2014

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