Development of a nanoparticle microfluidic colour device for point-of-care diagnostics Online publication date: Tue, 30-Sep-2014
by Saied Assadollahi; Roland Palkovits; Peter Pointl; Thomas Schalkhammer
International Journal of Design Engineering (IJDE), Vol. 4, No. 2, 2011
Abstract: Through a novel immunoassay nanoparticles (NPs) are captured via immune-reactive proteins and positioned as a sub-monolayer just a few nanometres above a light reflective surface. Here the particles and the mirror form a nanometric interference system with a tuneable colour throughout the full spectrum of light. This concept, which was inspired by nature ('wings of a butterfly'), creates an intensive colour clearly visible to the eye. By adaptation of this technique point-of-care (POC) tests become more sensitive, specific and time efficient. The novel format employs a combination of microfluidics and 'resonance-enhanced absorption' (REA) of gold and palladium nanoparticles quantifying interleukin-6 as an important parameter of acute sepsis. The colour intensity of the rapid test is boosted by using a subsequent silver enhancement. This performed in situ in just two to three minutes and a sensitivity of < 500 pg/ml was obtained.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Design Engineering (IJDE):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook